Best practice is to Avoid potholes.
Have always done this on my regular routes, but have been caught out lots of times on strange roads, even when looking far ahead (I'm a biker too) but so far no damage done. The 280 wheels are quite strong, and have only had the OE Bridgestones and Mich PSS on, I always use comfort mode in the winter as the softer setting is better for wet/snowy roads, so that may have helped too.